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Methods and Findings
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Methods Find Exp Clin Pharmacol 1999, 21(8): 523
ISSN 0379-0355
Copyright 1999 Clarivate
CCC: 0379-0355
DOI: 10.1358/mf.1999.21.8.794833
The morphine sparing effect of physostigmine
Patil, C.S., Kulkarni, S.K.
The antinociceptive effect of morphine was studied in tail-flick- and acetic acid-induced writhing in mice. Morphine effect was dose-related (1, 2 and 5 mg/kg s.c.). Physostigmine (0.05 and 0.1 mg/kg i.p.) potentiated the antinociceptive effect of morphine, and the anticholinergic, scopolamine (1 mg/kg i.p.), reversed the potentiating effect of physostigmine, indicating the involvement of the cholinergic system in pain. Coadministration of physostigmine would increase the therapeutic index of morphine thereby sparing the dose of morphine and also possibly the side effects including the development of tolerance and addiction.

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