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Methods and Findings
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Methods Find Exp Clin Pharmacol 2001, 23(1): 37
ISSN 0379-0355
Copyright 2001 Clarivate
CCC: 0379-0355
DOI: 10.1358/mf.2001.23.1.619178
Effect of omeprazole on the pharmacokinetics of sustained-release carbamazepine in healthy male volunteers
Dixit, R.K., Chawla, A.B., Kumar, N., Garg, S.K.
The present study shows the effect of omeprazole administration on the pharmacokinetics of a sustained-release preparation of carbamazepine in healthy male volunteers. Multiple dose administration of omeprazole increased the Cmax, AUC(0-inf.) and elimination half life (t1/2e) of carbamazepine. The results suggest that drug monitoring should be carried out when carbamazepine is coadministered with omeprazole.

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