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Methods and Findings
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Methods Find Exp Clin Pharmacol 1998, 20(1): 65
ISSN 0379-0355
Copyright 1998 Clarivate
CCC: 0379-0355
DOI: 10.1358/mf.1998.20.1.485634
The antistress effect of majonoside-R2, a major saponin component of Vietnamese ginseng: Neuronal mechanisms of action
Huong, N.T.T., Matsumoto, K., Watanabe, H.
Majonoside-R2 (MR2), an ocotillol-type saponin, is a dominant saponin component of Vietnamese ginseng. We have investigated the effect of MR2 on behavioral and pathophysiological changes caused by psychological stress such as the communication box paradigm-induced psychological stress (CBP stress), conditioned fear stress and social isolation stress in laboratory animals, and elucidated the possible neuronal mechanisms underlying the action of this compound. MR2 attenuated CBP stress- and conditioned fear stress-induced antinociception, had a protective effect against CBP stress-induced gastric lesions, and restored the hypnotic activity of pentobarbital decreased by CBP stress or social isolation stress to the level of the unstressed controls. Accumulating evidence strongly suggests the involvement of the central opioid, GABAA receptor and corticotropin-releasing factor mechanisms in the effect of MR2. Here, we review the antistress effect of Vietnamese ginseng, especially focusing on the effect of MR2 on psychomatic disorders caused by psychological stress.

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