|Methods and Findings|
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|Methods Find Exp Clin Pharmacol 2009, 31(2): 81|
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|Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum aqueous extract in animal models|
Zakaria, Z.A., Sulaiman, M.R., Morsid, N.A., Aris, A., Zainal, H., Pojan, N.H.M., Kumar, G.H.
|The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of the aqueous extract of Solanum nigrum leaves using various animal models. The extract, at concentrations of 10, 50 and 100%, was prepared by soaking (1:20; w/v) air-dried powdered leaves (20 g) in distilled water (dH2O) for 72 h. The extract solutions were administered subcutaneously in mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (P < 0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. Overall, these activities occurred in a concentration-dependent manner, except for the 50% concentration of the extract, which was not effective in the abdominal constriction test. In conclusion, the present study demonstrated that S. nigrum leaves possessed antinociceptive, anti-inflammatory and antipyretic effects and thus supported traditional claims of its medicinal uses.
Key words: Solanum nigrum - Aqueous extract - Antinociceptive - Anti-inflammatory - Antipyretic.|
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