Quick Search 
Methods and Findings
Register or sign in

  
 
  
Methods Find Exp Clin Pharmacol 2009, 31(2): 81
ISSN 0379-0355
Copyright 2009 Clarivate Analytics
CCC: 0379-0355
DOI: 10.1358/mf.2009.31.2.1353876
 
 
Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum aqueous extract in animal models
Zakaria, Z.A., Sulaiman, M.R., Morsid, N.A., Aris, A., Zainal, H., Pojan, N.H.M., Kumar, G.H.
 
 
The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of the aqueous extract of Solanum nigrum leaves using various animal models. The extract, at concentrations of 10, 50 and 100%, was prepared by soaking (1:20; w/v) air-dried powdered leaves (20 g) in distilled water (dH2O) for 72 h. The extract solutions were administered subcutaneously in mice/rats 30 min prior to the tests. The extract exhibited significant (P < 0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (P < 0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests, respectively. Overall, these activities occurred in a concentration-dependent manner, except for the 50% concentration of the extract, which was not effective in the abdominal constriction test. In conclusion, the present study demonstrated that S. nigrum leaves possessed antinociceptive, anti-inflammatory and antipyretic effects and thus supported traditional claims of its medicinal uses. Key words: Solanum nigrum - Aqueous extract - Antinociceptive - Anti-inflammatory - Antipyretic.


Full Text: HTMLPDF 
 
  



© Clarivate Analytics. All rights reserved.
Copyright NoticeTerms of UsePrivacy StatementCookie Policy