The field of siRNA-based theraeutics is rapidly progressing with the development of chemically modified siRNAs and a variety of novel delivery strategies.
RNA Interference for the Treatment of Cancer
by Lisa N. Putral, Wenyi Gu and Nigel A.J. McMillan
RNA interference (RNAi) is the latest new technology in the field of genetic medicine in which specific genes can be turned off, or silenced, so as to affect a therapeutic outcome. It can be highly specific, works in the nanomolar range and is far more effective than the antisense approaches popular 10-15 years ago. Here we review the field and explore the potential role of RNAi in cancer therapy, highlighting recent progress and examining the hurdles that must be overcome before this promising technology is ready for clinical use. © 2006 Prous Science. All rights reserved.