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Drug News Perspect 2004, 17(3): 165
ISSN 0214-0934
e-ISSN
Copyright 2004 Clarivate
CCC: 0214-0934
 

The detailed characterization of hOR17-4 as a representative human testicular olfactory receptor marks an important step toward a comprehensive understanding of the role(s) of olfactory receptor expression in sperm physiology.

hOR17-4 as a Potential Therapeutic Target

by Marc Spehr and Hanns Hatt


Summary

More than a decade ago, the unexpected finding of olfactory receptor expression in human testicular tissue led to speculation about a potential role of these chemoreceptors in various aspects of mature sperm behavior, especially sperm chemotaxis. Recently, first evidence in favor of this hypothesis was provided by the identification of hOR17-4, a testicular olfactory receptor that mediates human sperm chemotaxis in various bioassays. A detailed characterization of the receptor's molecular receptive range as well as the first description of a potent receptor antagonist could provide the basis for future applications in fertility treatment with important consequences in procreation and/or contraception. © 2004 Prous Science. All rights reserved.



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