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Methods and Findings
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Methods Find Exp Clin Pharmacol 2000, 22(9): 683
ISSN 0379-0355
Copyright 2000 Clarivate Analytics
CCC: 0379-0355
DOI: 10.1358/mf.2000.22.9.802284
 
 
Placental transfer of the antioxidant stobadine at different gestational stages in rabbits
Ujhazy, E., Dubovicky, M., Faberova, V., Zemanek, M., Soltes, L., Gajdosik, A., Eybl, V.
 
 
The distribution of [3H]-stobadine, a pyridoindole antioxidant, was investigated in New Zealand white rabbits and their fetuses on days 20 and 27 of gestation. The concentrations of [3H]-stobadine were determined in maternal and fetal organs after oral administration in a single dose of 5.0 mg/kg. The results of the study showed that during the late period of gestation the fetal organs, especially the brain and heart, were under the protective action of the antioxidant stobadine.


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