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Methods and Findings
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Methods Find Exp Clin Pharmacol 2000, 22(5): 309
ISSN 0379-0355
Copyright 2000 Clarivate Analytics
CCC: 0379-0355
DOI: 10.1358/mf.2000.22.5.796650
Theophylline for the treatment of bronchial asthma: Present status
Kawai, M., Kato, M.
Current Japanese asthma guidelines recommend theophylline as an additional regimen to inhaled b-agonists (on demand use) and inhaled corticosteroids (beclomethason dipropionate 200-1200 mcg/day or fluticason propionate 200-800 mcg/day) for patients whose asthma is not controlled completely. Similar recommendations are made in the International Consensus Report on Diagnosis and Treatment of Asthma. Recent advances in the understanding of its actions, especially regarding the antiinflammatory and immunomodulatory effects of low doses of theophylline, encourage its appropriate use in asthma treatment. Furthermore, asthma and chronic obstructive pulmonary disease (COPD) are considerably common diseases, and the economic benefits associated with the use of a relatively inexpensive, once or twice daily oral drug (intravenous infusion, if necessary) could be of importance. But, because of its narrow therapeutic range, dosage must be individualized in order to optimize the treatment based on the measurement of theophylline concentration in serum. Theophylline is an old medication with new forms. When used effectively and safely, it can have significant clinical benefits for patients. This paper intends to review the effectiveness of theophylline--historically and contemporarily.

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