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Methods and Findings
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Methods Find Exp Clin Pharmacol 2001, 23(9): 501
ISSN 0379-0355
Copyright 2001 Clarivate Analytics
CCC: 0379-0355
DOI: 10.1358/mf.2001.23.9.662137
 
 
Reversal of pyrogallol-induced delay in gastric emptying in rats by ginger (Zingiber officinale)
Gupta, Y.K., Sharma, M.
 
 
The effects of the acetone extract of ginger (Zingiber officinale) was studied against pyrogallol-induced delay in gastric emptying in rats. Wistar rats of either sex, weighing between 200-250 g, were used. Pyrogallol, at a dose of 100 mg/kg i.p., significantly delayed the gastric emptying of a methyl cellulose meal. One-hour pretreatment with ginger acetone extracts (100, 250 and 500 mg/kg p.o.) reversed the pyrogallol-induced delay in gastric emptying. The effect was significant at doses of 250 and 500 mg/kg. When the low dose of ginger (100 mg/kg p.o.) was given with vitamin C and vitamin E (100 mg/kg p.o., each), the reversal of gastric emptying was more pronounced than when only two vitamins or ginger (100 mg/kg and 500 mg/kg) were given alone. The present study indicates the potential of ginger in improving symptoms such as abdominal discomfort and bloating, which may accompany several gastrointestinal illnesses.


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