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Methods and Findings
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Methods Find Exp Clin Pharmacol 1998, 20(3): 211
ISSN 0379-0355
Copyright 1998 Clarivate Analytics
CCC: 0379-0355
Micronization: A method of improving the bioavailability of poorly soluble drugs
Chaumeil, J.C.
For poorly soluble drugs, the digestive absorption depends on their rate of dissolution. Decreasing the particle size of these drugs improves their rate of dissolution. Fine grinding mills are use to micronize powders: either jar mills or fluid energy mills. These processes were applied to griseofulvin, progesterone, spironolactone and diosmin. For each drug, micronization improved their digestive absorption, and consequently their bioavailability and clinical efficacy.

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