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Methods and Findings
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Methods Find Exp Clin Pharmacol 1998, 20(1): 39
ISSN 0379-0355
Copyright 1998 Clarivate Analytics
CCC: 0379-0355
DOI: 10.1358/mf.1998.20.1.485630
Effects of Toki-shakuyaku-san on electric footshock stress in ovariectomized mice
Iizuka, S., Ishige, A., Komatsu, Y., Matsumiya, T., Inazu, M., Takeda, H.
In the present study, ovariectomized mice were exposed to electric footshock stress for 7 days, and the duration of sodium pentobarbital-induced sleep was measured on the day following the last stress exposure. In ovariectomized mice, the duration of sodium pentobarbital-induced sleep before exposure to stress did not differ markedly from that in the sham-operation group. After exposure to stress, however, the duration of sodium pentobarbital-induced sleep in ovariectomized mice was shortened significantly, compared to the ovariectomized mice without stress. When the effect of Toki-shakuyaku-san on the stress-induced shortening of sleep time was studied, it was found that the shortening of the sleep time was suppressed by treatment with Toki-shakuyaku-san. In ovariectomized mice, the increase in hypothalamic noradrenaline (NA) turnover in response to stress was significantly greater than that in mice with intact ovaries. The stress-induced enhancement of NA turnover was suppressed significantly by Toki-shakuyaku-san in a dose-dependent manner, beginning with a low dose level. When the effect of 17beta-estradiol on the stress induced-shortening of sleep time was examined in ovariectomized mice, by high dose of 17beta-estradiol the shortening of the sleep time was prolonged. A major difference between 17beta-estradiol and Toki-shakuyaku-san was the marked uterine weight gain observed following 17beta-estradiol treatment despite no effect of Toki-shakuyaku-san on uterine weight. The results in this study suggest that Toki-shakuyaku-san may reduce menopausal symptoms by a mechanism different from that of estrogen.

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