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Methods and Findings
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Methods Find Exp Clin Pharmacol 2010, 32(6): 401
ISSN 0379-0355
Copyright 2010 Clarivate Analytics
CCC: 0379-0355
DOI: 10.1358/mf.2010.32.6.1514688
Influence of GABA-acting drugs on morphine-induced hyperthermia in rats
Nikolov, R.
A major inhibitory neurotransmitter of the nervous system, GABA (gamma-aminobutyric acid), is involved in mammalian thermoregulation. The present study investigated the influence of GABAergic neurotransmission-enhancing drugs, in a model of morphine-induced hyperthermia in conscious rats. We used body temperature assays to examine the effects of GABA-acting drugs on morphine-induced hyperthermia. In rats, low doses of morphine injected i.p. produced significant hyperthermia in a body temperature assay that was significantly attenuated upon pretreatment with GABA-acting drugs. These results suggest the existence of opioidergic-GABAergic interactions in a complex process of thermoregulation.

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