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Methods and Findings
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Methods Find Exp Clin Pharmacol 2008, 30(2): 103
ISSN 0379-0355
Copyright 2008 Clarivate
CCC: 0379-0355
DOI: 10.1358/mf.2008.30.2.1159655
Topical application of royal jelly has a healing effect for 5-fluorouracil-induced experimental oral mucositis in hamsters
Suemaru, K., Cui, R., Li, B., Watanabe, S., Okihara, K., Hashimoto, K., Yamada, H., Araki, H.
The aim of this study was to evaluate the effects of bee products such as honey, royal jelly and propolis on 5-fluorouracil-induced experimental oral mucositis in hamsters. Oral mucositis was induced in hamsters through a combination of 5-fluorouracil and mild abrasions that were made on the cheek pouch. Honey, royal jelly and propolis were thereafter topically administered to the oral mucosa, and then the healing process was examined by measuring the size of the mucositis. Honey (1%, 10% and 100%) and propolis (0.3%, 1% and 3%) ointments did not reduce the size of the mucositis in comparison to the vaseline-treated control group. However, the royal jelly (3%, 10% and 30%) ointments significantly improved the recovery from 5-fluorouracil-induced damage in a dose-dependent manner. These results suggest the possibility that the topical application of royal jelly has a healing effect on severe oral mucositis induced by chemotherapy.

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