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Drugs Today 2020, 56(5): 321
ISSN 1699-3993
Copyright 2020 Clarivate Analytics
CCC: 1699-3993
DOI: 10.1358/dot.2020.56.5.3134788
 
 
Drospirenone: a novel progestogen used as an oral contraceptive without an estrogen component
Paton, D.M.
 
 
Drospirenone (DRSP) was synthesized as an analogue of spironolactone with the aim of producing a fourth-generation progestogen that differed from earlier progestogens in that it had antiandrogenic and little or no androgenic activity and lacked estrogenic effects while retaining some antimineralocorticoid activity. Since then, DRSP has been included in several oral contraceptive preparations together with an estrogen. However, increasing evidence has demonstrated that DRSP 4 mg on its own inhibits ovulation. It was thus a logical development to determine the efficacy of a tablet that only included DRSP 4 mg as an oral contraceptive. This proved successful and this product has now been approved by the Food and Drug Administration (FDA).


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