The role the Jak-STAT pathway plays in the immune system makes it a prime target for therapeutic intervention.

JAK/STAT-Dependent Gene Regulation by Cytokines

by D. Hebenstreit, J. Horejs-Hoeck and A. Duschl

Summary

The Janus kinase-signal transducer and activator of transcription (Jak-STAT) pathway is essential for the signal transduction of many cytokines. Dysregulation of Jak-STAT signaling is associated with various human diseases. Recent studies have helped to shed some light on regulatory mechanisms that modify quantity and quality of the signaling response. Here, we summarize our current knowledge on Jak-STAT signaling. © 2005 Prous Science. All rights reserved.