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Drugs Fut 2021, 46(7): 529
ISSN 0377-8282
Copyright 2021 Clarivate
CCC: 0377-8282
DOI: 10.1358/dof.2021.46.7.3301491
Tezepelumab. Anti-TSLP (thymic stromal lymphopoietin), Treatment of severe asthma
Yao, Y., Ali, Z., Thomsen, S.F.
Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine of the interleukin-2 (IL-2) cytokine family with both homeostatic and inflammatory properties in the human organism. Aberrant production of TSLP has been observed in several type 2 allergic disorders such as bronchial asthma, atopic dermatitis and allergic rhinitis, prompting the development of anti-TSLP agents. In this review, we present the current known pharmacodynamics, pharmacokinetics, efficacy, safety and ongoing trials of tezepelumab. Tezepelumab (AMG-157, MEDI-9929) is a fully human immunoglobulin G subclass 2 (IgG2) anti-TSLP monoclonal antibody under investigation for the treatment of moderate to severe asthma. A phase II study has concluded that subcutaneously administered tezepelumab at doses of 210 mg every 4 weeks reduces exacerbation rates of asthma other than the type 2 endotype, improves lung function in asthmatic patients, and reduces levels of biomarkers of type 2 inflammation. Tezepelumab was generally well-tolerated with an acceptable safety profile and low rate of serious adverse events and discontinuations due to adverse events.

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